SNAP-8
SNAP-8
Acetyl Octapeptide-3 (SNAP-8)
High-Purity Laboratory Research Reagent
FOR LABORATORY USE ONLY. Not intended for therapeutic, diagnostic, or human/animal application.
Product Overview
Acetyl Octapeptide-3 (SNAP-8) is a premium, high-purity synthetic octapeptide reference compound structurally derived from the N-terminal region of SNAP-25. It is engineered specifically for institutional, laboratory-based biochemical and dermatological research. In contemporary in-vitro studies, it is primarily utilized to investigate SNARE-complex interaction pathways, vesicle-fusion signaling modulation, and surface-appearance benchmarking.
Technical Specifications
| Parameter | Specification |
| Product Ref | Acetyl Octapeptide-3 (Research Reagent) |
| IUPAC / INCI Name | Acetyl Octapeptide-3 |
| Chemical Class | Synthetic peptide / Signal-modulating octapeptide |
| Chemical Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| CAS Number | 868844-74-0 |
| Molecular Weight | ~889 g/mol |
| Amino Acid Count | 8 amino acids (Octapeptide) |
| Purity Standard | ≥99% (HPLC verified; MS identity confirmed; COA available) |
| Storage (Lyophilized) | 2–8°C in sealed research unit |
| Storage (Reconstituted) | −20°C (single-use aliquots recommended per lab protocol) |
| Shelf Life | 24 months from manufacture date (lyophilized, sealed, −20°C) |
Research Applications & Mechanisms
In highly controlled, cell-free laboratory environments, this octapeptide is utilized across several biochemical study areas:
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SNARE Complex Interaction Assays: Investigating competitive binding with SNAP-25 fragments within the SNARE complex using established biochemical assays.
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Vesicle-Fusion Signaling: Measuring the partial modulation of vesicle-fusion signaling pathways at defined laboratory concentrations.
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Delivery Efficiency Engineering: Evaluating stratum corneum permeation efficiency using advanced delivery models, such as dissolving microneedle (DMN) technology.
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Dual-Pathway Assays: Investigating combined, multi-pathway signaling interactions alongside complementary peptide reference compounds, such as Pentapeptide-18.
Comparative Research Context (Table 1)
| Peptide | Origin & Structure | Laboratory Target | Primary Research Focus | PubMed Ref |
| SNAP-8 | Synthetic octapeptide | SNARE-complex assays | Surface-appearance benchmarking | PMID: 33246344 |
| P21 (P021) | Small-molecule mimetic | BDNF-pathway modulation | Cellular neurogenesis models | PMID: 20600002 |
| Pinealon | Synthetic tripeptide | MAPK/ERK pathway | Cellular gene-expression models | PMID: 21978084 |
Why Source From Profound Aminos?
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Independent Identity Verification: Our reagent documentation is supported by laboratory-verified analytical benchmarks. Assays demonstrate that Acetyl Octapeptide-3 exhibits enhanced molecular stability compared to Acetyl Hexapeptide-8 at equivalent concentrations.
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Delivery Engineering Data: We provide comprehensive data summaries on device-enabled delivery systems. Published research suggests that Dissolving Microneedle (DMN) platforms can improve stratum corneum permeation efficiency up to 40-fold versus passive topical application.
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Regulatory & COA Transparency: We maintain strict compliance with federal research reagent standards (post-MoCRA). Every batch is accompanied by a Certificate of Analysis (COA) confirming purity and chemical identity via HPLC and Mass Spectrometry.
Regulatory & Safety Compliance
RESEARCH USE ONLY (RUO). This compound is supplied strictly for in-vitro biochemical testing, cellular assays, and laboratory calibration.
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Strict Prohibition: Any intent to use this product for internal or external human or animal application is a strict violation of federal regulations and our Terms of Service. Purchase constitutes an acknowledgment of its RUO-only status.
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Marketing Restrictions: No claims regarding physiological, therapeutic, cosmetic, or diagnostic outcomes are made or implied.
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Laboratory Handling Protocol: Researchers must adhere to institutional biosafety protocols and wear appropriate PPE (chemical-resistant gloves, eye protection) during reconstitution and handling. Always consult the Safety Data Sheet (SDS) for CAS 868844-74-0 prior to use.
Frequently Asked Questions
Is this product intended for human use, personal wellness, or self-administration?
No. Acetyl Octapeptide-3 is exclusively a Research Use Only (RUO) laboratory reagent for qualified institutional researchers.
Does this compound have FDA approval?
No. It is not approved for any therapeutic, cosmetic, dietary, or diagnostic indication.
How does SNAP-8 differ from Acetyl Hexapeptide-8 in laboratory settings?
It is a structurally extended iteration (eight amino acids instead of six) that is actively studied for potential differences in molecular stability and SNARE complex binding behaviors.
What is the primary challenge in topical peptide research?
The stratum corneum layer heavily restricts the passive permeation of large hydrophilic peptides, driving research into advanced delivery models like DMNs.
What concentrations should be utilized?
Researchers must consult the specific methodology sections of cited peer-reviewed literature for precise laboratory parameters, assay system requirements, and standardized concentrations.
Does the literature indicate complete pathway inhibition?
No. Published in-vitro data indicates partial modulation of vesicle-fusion signaling pathways, not complete inhibition.