TIRZEPATIDE

10mg

$99.00

$99.00

Choose an option 10mg 20mg 30mg 50mg

This 75-Format High-Mass Research Reagent empowers researchers to reconstitute a single, consistent master batch of lyophilized dual-agonist ligand (Tirzepatide) optimized for laboratory stock solutions. By enabling the creation of a unified master batch, it guarantees baseline uniformity for longitudinal metabolic in-vitro studies and thoroughly eliminates the inter-batch variance commonly associated with smaller aliquots.

Strictly for research purposes only. Not for human use.

Tirz 75 (High-Mass) | Dual-Agonist Ligand | CAS 2023788-19-2 | Profound Aminos

Technical Specifications

Specification	Detail
Product Ref	Tirz 75 (High-Mass Reagent)
Chemical Class	Dual-Agonist Peptide Ligand
CAS Number	2023788-19-2
Molecular Formula	$\text{C}_{225}\text{H}_{348}\text{N}_{48}\text{O}_{68}$
Molecular Weight	~4813.53 g/mol
Sequence Length	39 Amino Acids
Format	Lyophilized Filtered Cake
Mass Format	High-Mass Unit (75)
Purity	≥99% (RP-HPLC Verified)
Solubility	Soluble in BAC Water / Sterile Buffer
Storage	-20°C (Desiccated)
Disclaimer	For Research Use Only (RUO). Not for human use.

Product Overview

This product comprises a High-Mass Unit (75 Format) of the synthetic peptide ligand known as Tirz. It is a linear 39-amino acid chain that functions as a Dual-Agonist, targeting two distinct incretin receptor pathways simultaneously.

Unlike standard low-mass units often limited to single-assay use, this High-Mass Format is engineered specifically for high-throughput laboratories. It allows researchers to create a concentrated master stock solution, ensuring that every cellular culture or model in a longitudinal study receives an identical chemical concentration, thereby eliminating intra-experimental variability.

Research Mechanism

In modern metabolic research, this ligand is utilized in-vitro to study:

Synergistic Signaling: How activating the GIP receptor alongside the GLP-1 receptor alters cellular energy homeostasis.
Lipid Substrate Utilization: Investigating how dual-pathway modulation influences adipocyte (fat cell) metabolism in controlled environments.
Receptor Kinetics: Measuring binding affinity without the interference of systemic insulinogenic feedback loops.
Synergistic Mechanism of Action: Distinct from mono-target ligands, Tirz exhibits simultaneous affinity for both GIP and GLP-1 recognition sites. This dual-receptor occupancy modulates intracellular cAMP flux, facilitating the investigation of synergistic signaling pathways in isolated cell cultures.

Chemical Diagram of Tirz 75 (Placeholder for structural diagram) Tirz 75 High-Mass Lyophilized Reagent Vial for Stock Solution – GIP/GLP-1 Receptor Affinity Ligand – CAS 2023788-19-2

Comparative Research Context: Receptor Ligand Landscape

Feature	Tirz (Dual-A)	Sema (Single-A)	Reta (Triple-A)
Target Receptors	GIP + GLP-1	GLP-1 Only	GIP + GLP-1 + Glucagon
Primary Action	Synergistic Modulation	Agonist Signaling	Multi-Pathway Flux
Research Focus	Energy Homeostasis	Glycemic Indices	Basal Metabolic Rate
Assay Type	Dual-Receptor Binding	Single-Receptor Binding	Triple-Receptor Binding

Why Source From Profound Aminos

The "Single-Stock" Advantage Experimental error often occurs when researchers pool multiple small units together. Our Tirz 75 Format empowers you to reconstitute one large volume of reagent. This ensures absolute homogeneity across your entire experiment, significantly improving data reproducibility and $R^2$ values.
Cold-Chain Integrity Peptide ligands are highly sensitive to thermal degradation. We utilize a strictly monitored Cold-Chain Logistics protocol within the USA. Your reagent travels from a climate-controlled facility directly to your laboratory, preventing the molecular breakdown often seen in non-domestic or unmonitored shipments.
Sequence Integrity Verification Many generic sources offer high purity but broken peptide chains. We verify Peptide Integrity via Mass Spectrometry to ensure the full 39-amino acid sequence is completely intact and capable of successfully binding to both target receptors.

Regulatory & Compliance Statement (RUO)

Regulatory Classification & Usage Disclaimer:

Strictly RUO: This product is exclusively classified as a Research Use Only (RUO) reagent.
Chemical Reference Standard: It is supplied solely for in-vitro testing, cellular assays, and laboratory calibration.
Not a Drug: This compound has not been evaluated by the FDA for safety or efficacy in humans.
Handling Protocol: This reagent is a potent biological modulator. Researchers must wear appropriate PPE (nitrile gloves, protective eyewear, lab coat) during reconstitution and handling.
Safety Data: Always refer to the CAS 2023788-19-2 Material Safety Data Sheet (MSDS) before use.
Strict Prohibition: Any intent to use this product for bodily introduction (injection or ingestion) in humans or animals is a direct violation of federal compliance protocols.

Frequently Asked Questions

Q1: Is this product intended for human use? A: NO. This is strictly a Chemical Reference Material for laboratory research. It is not a sterile pharmaceutical product and is not approved for human consumption, therapeutic application, or clinical diagnostics.

Q2: What does "75 Format" mean? A: This refers to the total mass of the active lyophilized powder inside the container. It is specifically designed for preparing large-volume master stock solutions for multiple assays or longitudinal experiments.

Q3: How do I dissolve the lyophilized cake? A: The reagent is soluble in BAC Water or an appropriate sterile buffer solution. Researchers must calculate the molarity required for their specific assay before adding the solvent to ensure accurate concentrations.

Q4: Can I freeze the solution after mixing? A: Yes. Once reconstituted, we strongly recommend aliquoting the master solution into smaller, single-use units and storing them at -80°C. This prevents repeated freeze-thaw cycles, which will rapidly degrade the peptide sequence.

Q5: Does this ligand display cross-reactivity with Tyrosine Kinase vectors? A: It maintains a High Selectivity Profile. Structural binding assays confirm that Tirz is highly selective for G-Protein Coupled Receptors (GPCRs). It displays negligible binding affinity for the Tyrosine Kinase family, empowering researchers to isolate incretin signaling pathways without interference from divergent metabolic cascades.

Q6: Why is the powder quantity visually small? A: The lyophilization (freeze-drying) process removes all moisture, leaving a highly dense "cake" at the base of the vial. While the visual volume may appear small, the actual Mass Content is gravimetrically guaranteed.

Q7: Does this ligand interact with Nuclear Receptors? A: No. This is a Peptide-Based Agonist. It strictly targets extracellular G-Protein Coupled Receptors (GPCRs) and does not share chemical properties with cholesterol-derived scaffolds or intracellular nuclear signaling agents.

Q8: What is the shelf life? A: In its lyophilized (powder) state, it is stable for up to 24 months if stored desiccated at -20°C. Once dissolved in a solvent, it should be utilized immediately in your assay or frozen in aliquots at -80°C.

Q9: Do you provide a Certificate of Analysis (COA)? A: Yes. Every batch includes a COA verifying ≥99% purity and identity confirmation via both RP-HPLC and Mass Spectrometry.

Q10: Can this be used for "Biohacking"? A: Absolutely Not. Any reference to personal use, biohacking, or lifestyle improvement blatantly violates our Terms of Service and will result in the immediate cancellation of the order and a permanent ban from our supply network.