Tesamorelin (RUO) – Research-Grade Peptide | COA Verified | USA

IMPORTANT NOTICE: Tesamorelin is a synthetic peptide analogue of the human growth hormone-releasing hormone (GHRH). This material is supplied strictly for Research Use Only (RUO) and is not intended for human or veterinary use. It is utilized exclusively in laboratory settings for in vitro and preclinical experimental models regarding the somatotropic axis and metabolic pathways. Profound Aminos makes no therapeutic, diagnostic, or medical claims regarding this compound.

Product Specifications

Chemical Identity & Characteristics

Tesamorelin is a 44-amino acid polypeptide sequence homologous to the N-terminal fragment of human GHRH. It is distinct from native GHRH due to a specific structural modification: the addition of a trans-3-hexenoyl group at the N-terminal.

In research applications, this hexenoyl moiety is investigated for its ability to provide steric shielding. This potentially increases the peptide's resistance to enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4) in experimental substrates. This structural modification remains a key subject of study regarding peptide stability and pharmacodynamics when compared to native GHRH sequences.

(Note for web placement: Insert your illustration of the Tesamorelin peptide chain structure and highlighted functional groups here.)

Analytical Validation & Quality Assurance

Profound Aminos places a strong emphasis on analytical transparency across all research materials. Every batch of Tesamorelin is thoroughly tested to confirm both identity and purity.

• High-Performance Liquid Chromatography (HPLC): Evaluates peptide purity (≥99%) and detects potential impurities.

• Mass Spectrometry (MS): Confirms the molecular weight (~5135.9 Da) and verifies absolute sequence identity.

• Certificate of Analysis (COA): Provided for each lot, giving researchers clear traceability and assurance that the material meets stringent specifications prior to shipment.

Storage, Stability & Handling

To maintain the stability and integrity of this hygroscopic material, strict adherence to laboratory protocols is required:

• Storage Environment: Unopened vials must be stored in a freezer at -20°C.

• Protection: Keep vials completely shielded from direct light and ambient moisture.

• Preparation: Allow the vial to reach room temperature before opening to prevent condensation and moisture absorption.

• Reconstitution: For laboratory preparation and analytical procedures only. Once reconstituted in an appropriate aqueous solvent, the solution should be refrigerated and utilized within a short timeframe according to standard peptide handling protocols.

Research Context & Literature Overview

Tesamorelin has been the subject of extensive investigation in metabolic and neuroendocrine research. Scientific literature characterizes the compound as a GHRH agonist that binds to specific receptors on anterior pituitary somatotrophs. Preclinical models and published studies report the following mechanistic observations:

• Somatotropic Axis: Research indicates the compound may stimulate the pulsatile release of endogenous growth hormone (GH) in test subjects, maintaining standard negative feedback loops via IGF-1.

• Lipolytic Pathways: Experimental models explore the peptide’s selectivity for visceral adipose tissue modulation, specifically investigating the regulation of enzymes like lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL).

• Hepatic Research: Studies examine the effects of GHRH analogues on hepatic physiology, specifically focusing on mitochondrial oxidation and de novo lipogenesis pathways in models of hepatic steatosis.

• Neuroregeneration: Emerging studies (e.g., Johns Hopkins University) are actively investigating the potential role of GHRH agonists in peripheral nerve regeneration and axonal outgrowth in injury models.

Cited Research & Clinical Literature

The following references are provided strictly for educational and research purposes to describe the peptide’s mechanism of action and historical context. They do not imply efficacy or therapeutic use for this RUO chemical reagent.

• New England Journal of Medicine (2007): "Metabolic effects of a growth hormone-releasing factor in patients with HIV." (Grinspoon et al.) – A foundational study characterizing the metabolic profile and pharmacodynamics of the peptide in specific metabolic dysregulation cohorts.

• The Lancet HIV (2019): "Effects of tesamorelin on non-alcoholic fatty liver disease in HIV." (Stanley et al.) – Documented the effects of the peptide on hepatic fat fraction and fibrosis markers in randomized controlled settings.

• Journal of Clinical Endocrinology & Metabolism (2010): "Effects of tesamorelin… a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials." (Falutz et al.) – Detailed efficacy data regarding visceral adipose tissue modulation and safety parameters.

• AIDS (2024): "Efficacy and Safety of Tesamorelin in People with HIV on Integrase Inhibitors." (Russo et al.) – A recent analysis examining the peptide’s interaction with modern regimens and its influence on visceral adiposity and hepatic parameters.

Why Researchers Source from Profound Aminos

Profound Aminos provides research chemicals with an unwavering focus on analytical transparency, batch-level traceability, and strict RUO compliance to ensure reliable, reproducible data.

• Traceability: Verified batch data ensures you know exactly what is in your reagent.

• Documentation: Clear, accessible COAs support your laboratory’s rigorous quality control requirements.

• Compliance: A strict Research Use Only policy ensures products are reserved exclusively for qualified researchers conducting legitimate scientific work.

• Integrity: Peptides are handled, stored, and shipped under tightly controlled conditions to preserve experimental reliability.

Regulatory & Compliance Statement

For Research Use Only (RUO). This product is intended solely for laboratory research and development. It is not for human or veterinary use. It is not a food, drug, or cosmetic. No medical, therapeutic, or diagnostic claims are made regarding this product. All handling must be performed by qualified professionals in an appropriate laboratory setting.

Frequently Asked Questions (FAQs)

Is this peptide for research use only?

Yes. Tesamorelin is supplied strictly for laboratory research and analytical use. It is not for human consumption, clinical application, or therapeutic administration.

Is a Certificate of Analysis (COA) available?

Yes. A batch-specific Certificate of Analysis (COA) demonstrating HPLC and MS data is readily available for review and verification.

How is purity verified?

Purity is verified using High-Performance Liquid Chromatography (HPLC) to ensure the compound meets strict research-grade specifications (≥99%).

Is USA shipping available?

Yes. We ship directly from our climate-controlled facility within the USA to ensure rapid delivery and maximum product stability.