{"product_id":"tesamorelin","title":"TESAMORELIN","description":"\u003ch1 data-path-to-node=\"2\"\u003eTesamorelin (RUO) – Research-Grade Peptide | COA Verified | USA\u003c\/h1\u003e\n\u003cblockquote data-path-to-node=\"3\"\u003e\n\u003cp data-path-to-node=\"3,0\"\u003e\u003cb data-path-to-node=\"3,0\" data-index-in-node=\"0\"\u003eIMPORTANT NOTICE:\u003c\/b\u003e Tesamorelin is a synthetic peptide analogue of the human growth hormone-releasing hormone (GHRH). This material is supplied strictly for \u003cb data-path-to-node=\"3,0\" data-index-in-node=\"155\"\u003eResearch Use Only (RUO)\u003c\/b\u003e and is not intended for human or veterinary use. It is utilized exclusively in laboratory settings for \u003ci data-path-to-node=\"3,0\" data-index-in-node=\"282\"\u003ein vitro\u003c\/i\u003e and preclinical experimental models regarding the somatotropic axis and metabolic pathways. Profound Aminos makes no therapeutic, diagnostic, or medical claims regarding this compound.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch2 data-path-to-node=\"5\"\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable data-path-to-node=\"6\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSpecification\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eDetail\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,1,0,0\"\u003e\u003cb data-path-to-node=\"6,1,0,0\" data-index-in-node=\"0\"\u003eProduct Name\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,1,1,0\"\u003eTesamorelin (Tesamorelin Acetate)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,2,0,0\"\u003e\u003cb data-path-to-node=\"6,2,0,0\" data-index-in-node=\"0\"\u003eProduct Type\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,2,1,0\"\u003eSynthetic GHRH Analogue\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,3,0,0\"\u003e\u003cb data-path-to-node=\"6,3,0,0\" data-index-in-node=\"0\"\u003eSequence Length\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,3,1,0\"\u003e44 Amino Acids\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,4,0,0\"\u003e\u003cb data-path-to-node=\"6,4,0,0\" data-index-in-node=\"0\"\u003eMolecular Weight\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,4,1,0\"\u003e~5135.9 Da\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,5,0,0\"\u003e\u003cb data-path-to-node=\"6,5,0,0\" data-index-in-node=\"0\"\u003ePurity\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,5,1,0\"\u003e≥99% (HPLC Verified)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,6,0,0\"\u003e\u003cb data-path-to-node=\"6,6,0,0\" data-index-in-node=\"0\"\u003eSolubility\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,6,1,0\"\u003eCompatible with commonly used laboratory-grade aqueous solvents\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,7,0,0\"\u003e\u003cb data-path-to-node=\"6,7,0,0\" data-index-in-node=\"0\"\u003eForm\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,7,1,0\"\u003eSterile, Lyophilized Powder\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,8,0,0\"\u003e\u003cb data-path-to-node=\"6,8,0,0\" data-index-in-node=\"0\"\u003eStorage\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"6,8,1,0\"\u003eStore at -20°C, protected from light and moisture\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2 data-path-to-node=\"8\"\u003eChemical Identity \u0026amp; Characteristics\u003c\/h2\u003e\n\u003cp data-path-to-node=\"9\"\u003eTesamorelin is a 44-amino acid polypeptide sequence homologous to the N-terminal fragment of human GHRH. It is distinct from native GHRH due to a specific structural modification: the addition of a \u003cb data-path-to-node=\"9\" data-index-in-node=\"198\"\u003etrans-3-hexenoyl group\u003c\/b\u003e at the N-terminal.\u003c\/p\u003e\n\u003cp data-path-to-node=\"10\"\u003eIn research applications, this hexenoyl moiety is investigated for its ability to provide steric shielding. This potentially increases the peptide's resistance to enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4) in experimental substrates. This structural modification remains a key subject of study regarding peptide stability and pharmacodynamics when compared to native GHRH sequences.\u003c\/p\u003e\n\u003cp data-path-to-node=\"11\"\u003e\u003ci data-path-to-node=\"11\" data-index-in-node=\"0\"\u003e(Note for web placement: Insert your illustration of the Tesamorelin peptide chain structure and highlighted functional groups here.)\u003c\/i\u003e\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"13\"\u003eAnalytical Validation \u0026amp; Quality Assurance\u003c\/h2\u003e\n\u003cp data-path-to-node=\"14\"\u003eProfound Aminos places a strong emphasis on analytical transparency across all research materials. Every batch of Tesamorelin is thoroughly tested to confirm both identity and purity.\u003c\/p\u003e\n\u003cul data-path-to-node=\"15\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"15,0,0\"\u003e\u003cb data-path-to-node=\"15,0,0\" data-index-in-node=\"0\"\u003eHigh-Performance Liquid Chromatography (HPLC):\u003c\/b\u003e Evaluates peptide purity (≥99%) and detects potential impurities.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"15,1,0\"\u003e\u003cb data-path-to-node=\"15,1,0\" data-index-in-node=\"0\"\u003eMass Spectrometry (MS):\u003c\/b\u003e Confirms the molecular weight (~5135.9 Da) and verifies absolute sequence identity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"15,2,0\"\u003e\u003cb data-path-to-node=\"15,2,0\" data-index-in-node=\"0\"\u003eCertificate of Analysis (COA):\u003c\/b\u003e Provided for each lot, giving researchers clear traceability and assurance that the material meets stringent specifications prior to shipment.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"17\"\u003eStorage, Stability \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-path-to-node=\"18\"\u003eTo maintain the stability and integrity of this hygroscopic material, strict adherence to laboratory protocols is required:\u003c\/p\u003e\n\u003cul data-path-to-node=\"19\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,0,0\"\u003e\u003cb data-path-to-node=\"19,0,0\" data-index-in-node=\"0\"\u003eStorage Environment:\u003c\/b\u003e Unopened vials must be stored in a freezer at \u003cb data-path-to-node=\"19,0,0\" data-index-in-node=\"67\"\u003e-20°C\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,1,0\"\u003e\u003cb data-path-to-node=\"19,1,0\" data-index-in-node=\"0\"\u003eProtection:\u003c\/b\u003e Keep vials completely shielded from direct light and ambient moisture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,2,0\"\u003e\u003cb data-path-to-node=\"19,2,0\" data-index-in-node=\"0\"\u003ePreparation:\u003c\/b\u003e Allow the vial to reach room temperature before opening to prevent condensation and moisture absorption.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,3,0\"\u003e\u003cb data-path-to-node=\"19,3,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e For laboratory preparation and analytical procedures only. Once reconstituted in an appropriate aqueous solvent, the solution should be refrigerated and utilized within a short timeframe according to standard peptide handling protocols.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"21\"\u003eResearch Context \u0026amp; Literature Overview\u003c\/h2\u003e\n\u003cp data-path-to-node=\"22\"\u003eTesamorelin has been the subject of extensive investigation in metabolic and neuroendocrine research. Scientific literature characterizes the compound as a GHRH agonist that binds to specific receptors on anterior pituitary somatotrophs. Preclinical models and published studies report the following mechanistic observations:\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-path-to-node=\"23,0,0\" data-index-in-node=\"0\"\u003eSomatotropic Axis:\u003c\/b\u003e Research indicates the compound may stimulate the pulsatile release of endogenous growth hormone (GH) in test subjects, maintaining standard negative feedback loops via IGF-1.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-path-to-node=\"23,1,0\" data-index-in-node=\"0\"\u003eLipolytic Pathways:\u003c\/b\u003e Experimental models explore the peptide’s selectivity for visceral adipose tissue modulation, specifically investigating the regulation of enzymes like lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,2,0\"\u003e\u003cb data-path-to-node=\"23,2,0\" data-index-in-node=\"0\"\u003eHepatic Research:\u003c\/b\u003e Studies examine the effects of GHRH analogues on hepatic physiology, specifically focusing on mitochondrial oxidation and \u003ci data-path-to-node=\"23,2,0\" data-index-in-node=\"140\"\u003ede novo\u003c\/i\u003e lipogenesis pathways in models of hepatic steatosis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,3,0\"\u003e\u003cb data-path-to-node=\"23,3,0\" data-index-in-node=\"0\"\u003eNeuroregeneration:\u003c\/b\u003e Emerging studies (e.g., Johns Hopkins University) are actively investigating the potential role of GHRH agonists in peripheral nerve regeneration and axonal outgrowth in injury models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"24\"\u003eCited Research \u0026amp; Clinical Literature\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003ci data-path-to-node=\"25\" data-index-in-node=\"0\"\u003eThe following references are provided strictly for educational and research purposes to describe the peptide’s mechanism of action and historical context. They do not imply efficacy or therapeutic use for this RUO chemical reagent.\u003c\/i\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eNew England Journal of Medicine (2007):\u003c\/b\u003e \u003ci data-path-to-node=\"26,0,0\" data-index-in-node=\"40\"\u003e\"Metabolic effects of a growth hormone-releasing factor in patients with HIV.\"\u003c\/i\u003e (Grinspoon et al.) – A foundational study characterizing the metabolic profile and pharmacodynamics of the peptide in specific metabolic dysregulation cohorts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eThe Lancet HIV (2019):\u003c\/b\u003e \u003ci data-path-to-node=\"26,1,0\" data-index-in-node=\"23\"\u003e\"Effects of tesamorelin on non-alcoholic fatty liver disease in HIV.\"\u003c\/i\u003e (Stanley et al.) – Documented the effects of the peptide on hepatic fat fraction and fibrosis markers in randomized controlled settings.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,2,0\"\u003e\u003cb data-path-to-node=\"26,2,0\" data-index-in-node=\"0\"\u003eJournal of Clinical Endocrinology \u0026amp; Metabolism (2010):\u003c\/b\u003e \u003ci data-path-to-node=\"26,2,0\" data-index-in-node=\"55\"\u003e\"Effects of tesamorelin… a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials.\"\u003c\/i\u003e (Falutz et al.) – Detailed efficacy data regarding visceral adipose tissue modulation and safety parameters.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,3,0\"\u003e\u003cb data-path-to-node=\"26,3,0\" data-index-in-node=\"0\"\u003eAIDS (2024):\u003c\/b\u003e \u003ci data-path-to-node=\"26,3,0\" data-index-in-node=\"13\"\u003e\"Efficacy and Safety of Tesamorelin in People with HIV on Integrase Inhibitors.\"\u003c\/i\u003e (Russo et al.) – A recent analysis examining the peptide’s interaction with modern regimens and its influence on visceral adiposity and hepatic parameters.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"28\"\u003eWhy Researchers Source from Profound Aminos\u003c\/h2\u003e\n\u003cp data-path-to-node=\"29\"\u003eProfound Aminos provides research chemicals with an unwavering focus on analytical transparency, batch-level traceability, and strict RUO compliance to ensure reliable, reproducible data.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eTraceability:\u003c\/b\u003e Verified batch data ensures you know exactly what is in your reagent.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eDocumentation:\u003c\/b\u003e Clear, accessible COAs support your laboratory’s rigorous quality control requirements.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eCompliance:\u003c\/b\u003e A strict Research Use Only policy ensures products are reserved exclusively for qualified researchers conducting legitimate scientific work.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eIntegrity:\u003c\/b\u003e Peptides are handled, stored, and shipped under tightly controlled conditions to preserve experimental reliability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"32\"\u003eRegulatory \u0026amp; Compliance Statement\u003c\/h2\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFor Research Use Only (RUO).\u003c\/b\u003e This product is intended solely for laboratory research and development. It is not for human or veterinary use. It is not a food, drug, or cosmetic. No medical, therapeutic, or diagnostic claims are made regarding this product. All handling must be performed by qualified professionals in an appropriate laboratory setting.\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"35\"\u003eFrequently Asked Questions (FAQs)\u003c\/h2\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eIs this peptide for research use only?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"36\"\u003eYes. Tesamorelin is supplied strictly for laboratory research and analytical use. It is not for human consumption, clinical application, or therapeutic administration.\u003c\/p\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eIs a Certificate of Analysis (COA) available?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"37\"\u003eYes. A batch-specific Certificate of Analysis (COA) demonstrating HPLC and MS data is readily available for review and verification.\u003c\/p\u003e\n\u003cp data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eHow is purity verified?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"38\"\u003ePurity is verified using High-Performance Liquid Chromatography (HPLC) to ensure the compound meets strict research-grade specifications (≥99%).\u003c\/p\u003e\n\u003cp data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eIs USA shipping available?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"39\"\u003eYes. We ship directly from our climate-controlled facility within the USA to ensure rapid delivery and maximum product stability.\u003c\/p\u003e","brand":"BioLink Analytica","offers":[{"title":"5mg","offer_id":45054253760581,"sku":"TSM5","price":59.0,"currency_code":"USD","in_stock":false},{"title":"10mg","offer_id":45054302027845,"sku":"TSM10","price":75.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0729\/0060\/8069\/files\/TSM5.png?v=1782365654","url":"https:\/\/www.biolinkanalytica.com\/products\/tesamorelin","provider":"BioLink Analytica","version":"1.0","type":"link"}