{"product_id":"tb500","title":"TB500","description":"\u003ch1 data-path-to-node=\"2\"\u003eTB 500 (Thymosin Beta-4 Fragment)\u003c\/h1\u003e\n\u003cp data-path-to-node=\"3\"\u003e\u003cb data-path-to-node=\"3\" data-index-in-node=\"0\"\u003eCellular Regeneration \u0026amp; Actin-Binding Research Compound\u003c\/b\u003e\u003c\/p\u003e\n\u003cblockquote data-path-to-node=\"4\"\u003e\n\u003cp data-path-to-node=\"4,0\"\u003e\u003cb data-path-to-node=\"4,0\" data-index-in-node=\"0\"\u003e🚨 DISCLAIMER:\u003c\/b\u003e \u003cb data-path-to-node=\"4,0\" data-index-in-node=\"15\"\u003eFor Research Use Only (RUO).\u003c\/b\u003e Not for human or veterinary use. The information presented is derived from published scientific literature and is intended solely for laboratory and academic reference.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp data-path-to-node=\"5\"\u003eTB 500 is a high-purity synthetic peptide fragment of Thymosin Beta-4, extensively studied for its impact on cellular migration, actin regulation, and wound-healing pathways. It provides researchers with a reproducible experimental model for investigating tissue regeneration, angiogenesis, and cytoskeletal organization under controlled laboratory conditions.\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"7\"\u003e📊 Product Specifications\u003c\/h2\u003e\n\u003ctable data-path-to-node=\"8\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSpecification\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eDetail\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,1,0,0\"\u003e\u003cb data-path-to-node=\"8,1,0,0\" data-index-in-node=\"0\"\u003eFormula\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,1,1,0\"\u003eSynthetic peptide fragment derived from Thymosin Beta-4 (Ac-SDKP analog)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,2,0,0\"\u003e\u003cb data-path-to-node=\"8,2,0,0\" data-index-in-node=\"0\"\u003eMolecular Weight\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,2,1,0\"\u003e~4963 Da\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,3,0,0\"\u003e\u003cb data-path-to-node=\"8,3,0,0\" data-index-in-node=\"0\"\u003ePurity\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,3,1,0\"\u003e≥99% (HPLC verified)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,4,0,0\"\u003e\u003cb data-path-to-node=\"8,4,0,0\" data-index-in-node=\"0\"\u003eSolubility\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,4,1,0\"\u003eSoluble in sterile water or phosphate-buffered saline (PBS)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,5,0,0\"\u003e\u003cb data-path-to-node=\"8,5,0,0\" data-index-in-node=\"0\"\u003eStorage\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"8,5,1,0\"\u003e–20°C, protected from light and moisture\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2 data-path-to-node=\"10\"\u003e🧬 Description \u0026amp; Research Scope\u003c\/h2\u003e\n\u003ch3 data-path-to-node=\"11\"\u003eOverview\u003c\/h3\u003e\n\u003cp data-path-to-node=\"12\"\u003eTB 500 is a well-characterized peptide widely used in laboratory research to understand cellular regeneration and actin-mediated repair mechanisms. Thymosin Beta-4, originally isolated from the thymus gland, plays a central role in cytoskeletal reorganization, cell movement, and differentiation. Its synthetic counterpart, TB-500, preserves the core bioactive region responsible for actin-binding, making it a highly valuable reagent for molecular and cell biology studies.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"13\"\u003eActin Dynamics, Cell Migration, and Angiogenesis\u003c\/h3\u003e\n\u003cp data-path-to-node=\"14\"\u003eIn cellular models, actin is one of the most abundant proteins, forming dynamic filament networks that define cell structure and motility.\u003c\/p\u003e\n\u003cul data-path-to-node=\"15\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"15,0,0\"\u003e\u003cb data-path-to-node=\"15,0,0\" data-index-in-node=\"0\"\u003eCytoskeletal Modulation:\u003c\/b\u003e TB 500 regulates the equilibrium between globular (G-actin) and filamentous (F-actin) forms, enabling scientists to observe how this modulation influences cell migration and tissue repair.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"15,1,0\"\u003e\u003cb data-path-to-node=\"15,1,0\" data-index-in-node=\"0\"\u003eCellular Injury Models:\u003c\/b\u003e Experimental findings demonstrate that TB 500 enhances the movement of keratinocytes and endothelial cells to sites of cellular injury, providing insights into how tissues regenerate following oxidative or mechanical stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"15,2,0\"\u003e\u003cb data-path-to-node=\"15,2,0\" data-index-in-node=\"0\"\u003eAngiogenesis:\u003c\/b\u003e Laboratory assays show increased endothelial cell organization and migration. TB 500 is believed to upregulate actin-binding proteins that facilitate cytoskeletal remodeling, providing insight into the regulation of growth factors such as VEGF and TGF-β.\u003cbr\u003e\u003cimg src=\"https:\/\/cdn-iledacd.nitrocdn.com\/SjFAtUDKoxpKJBWpudFZVunbmeIDeGio\/assets\/images\/optimized\/rev-6c455cf\/profoundaminos.com\/wp-content\/uploads\/2025\/10\/Molecular-Structure-details-of-TB-500-thymosin-Beta-4-Fragment-300x200.webp\" alt=\"TB 500 molecular structure diagram showing the Thymosin Beta-4 fragment with labeled residues, molecular formula C221H364N56O68S, and molecular weight 4963.48 Da\"\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"16\"\u003eMulti-Peptide Synergy (BPC-157 \u0026amp; GHK-Cu)\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003eIn advanced research, TB 500 is frequently studied alongside \u003cb data-path-to-node=\"17\" data-index-in-node=\"61\"\u003eBPC-157\u003c\/b\u003e and \u003cb data-path-to-node=\"17\" data-index-in-node=\"73\"\u003eGHK-Cu\u003c\/b\u003e to assess multi-peptide synergy. These comparative analyses allow researchers to observe how peptide families coordinate to promote cytoskeletal stability, gene repair signaling, and oxidative protection, expanding the scope of regenerative peptide biology.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"18\"\u003eInflammatory Modulation \u0026amp; Immune Signaling\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eTB 500 provides a robust platform for studying inflammatory modulation. Preclinical investigations show it influences macrophage polarization and cytokine balance—key factors determining the quality and duration of the inflammatory response during cellular recovery.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"20\"\u003eAnalytical Quality \u0026amp; Handling\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eTB 500’s high purity (≥99%, HPLC-verified) ensures absolute reproducibility in cell migration assays, scratch models, and protein expression studies. It remains chemically stable under appropriate storage conditions and dissolves easily in standard aqueous buffers.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"22\"\u003eSummary\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003eTB 500 stands as an essential compound for modern peptide-based research. Its unique actin-binding mechanism, reproducible biological activity, and compatibility with multi-peptide systems make it a cornerstone in regenerative studies, providing valuable data for the evolving field of molecular regeneration science.\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"25\"\u003e✨ Features \u0026amp; Highlights\u003c\/h2\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eTargeted Mechanism:\u003c\/b\u003e Supports actin regulation and cellular migration research.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eTissue Repair:\u003c\/b\u003e Enables studies on angiogenesis and wound-healing pathways.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,2,0\"\u003e\u003cb data-path-to-node=\"26,2,0\" data-index-in-node=\"0\"\u003ePremium Quality:\u003c\/b\u003e Validated purity (≥99%, HPLC-tested) for consistent, reproducible results in \u003ci data-path-to-node=\"26,2,0\" data-index-in-node=\"94\"\u003ein-vitro\u003c\/i\u003e systems.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,3,0\"\u003e\u003cb data-path-to-node=\"26,3,0\" data-index-in-node=\"0\"\u003eSynergistic Potential:\u003c\/b\u003e Compatible with BPC-157 and GHK-Cu for advanced multi-peptide research models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,4,0\"\u003e\u003cb data-path-to-node=\"26,4,0\" data-index-in-node=\"0\"\u003eCompliance:\u003c\/b\u003e Designed strictly for Research Use Only (RUO) standards.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"28\"\u003e🧊 Storage Instructions\u003c\/h2\u003e\n\u003cp data-path-to-node=\"29\"\u003eTo maintain purity and structural integrity for long-term research stability, please adhere to the following guidelines:\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003eStore at \u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"9\"\u003e−20°C\u003c\/b\u003e in a tightly sealed container.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003eProtect completely from light and moisture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003eAvoid repeated freeze–thaw cycles.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003ci data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e(Note: Molecular Structure diagram to be inserted here based on your specific rendering\/image files).\u003c\/i\u003e\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"33\"\u003e📚 Selected Research References\u003c\/h2\u003e\n\u003col start=\"1\" data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003eHuff, T. et al. (2001).\u003c\/b\u003e \u003ci data-path-to-node=\"34,0,0\" data-index-in-node=\"24\"\u003e\"Thymosin Beta-4 Is a Major Cellular Actin-Sequestering Protein.\"\u003c\/i\u003e J. Biol. Chem.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eMalinda, K. M. et al. (1999).\u003c\/b\u003e \u003ci data-path-to-node=\"34,1,0\" data-index-in-node=\"30\"\u003e\"Thymosin Beta-4 Accelerates Wound Healing.\"\u003c\/i\u003e J. Invest. Dermatol.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eGoldstein, A. L. et al. (2012).\u003c\/b\u003e \u003ci data-path-to-node=\"34,2,0\" data-index-in-node=\"32\"\u003e\"Regenerative Effects of Thymosin Beta-4 Derivatives in Animal Models.\"\u003c\/i\u003e Ann. N.Y. Acad. Sci.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eSosne, G. et al. (2015).\u003c\/b\u003e \u003ci data-path-to-node=\"34,3,0\" data-index-in-node=\"25\"\u003e\"Mechanistic Insights into Thymosin Peptides in Cellular Migration and Repair.\"\u003c\/i\u003e Exp. Eye Res.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch2 data-path-to-node=\"36\"\u003e❓ Frequently Asked Questions (FAQs)\u003c\/h2\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eQ1: What is TB 500 used for?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"29\"\u003eA1:\u003c\/b\u003e TB 500 is used for laboratory research exploring actin regulation, cell migration, angiogenesis, and wound-healing mechanisms.\u003c\/p\u003e\n\u003cp data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eQ2: Is TB 500 identical to Thymosin Beta-4?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"44\"\u003eA2:\u003c\/b\u003e No. TB 500 is a synthetic fragment representing the primary bioactive region of Thymosin Beta-4, optimized specifically for laboratory reproducibility.\u003c\/p\u003e\n\u003cp data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eQ3: What purity levels are required for TB 500 research?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"57\"\u003eA3:\u003c\/b\u003e High-purity TB 500 (≥99%, HPLC verified) is required to ensure consistent and reliable results across delicate molecular and cellular studies.\u003c\/p\u003e\n\u003cp data-path-to-node=\"40\"\u003e\u003cb data-path-to-node=\"40\" data-index-in-node=\"0\"\u003eQ4: Can TB 500 be used in humans or animals?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"40\"\u003e\u003cb data-path-to-node=\"40\" data-index-in-node=\"45\"\u003eA4:\u003c\/b\u003e No. TB 500 is strictly for Research Use Only and is not intended for human consumption or veterinary applications.\u003c\/p\u003e\n\u003cp data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eQ5: How is TB 500 stored for long-term research stability?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"59\"\u003eA5:\u003c\/b\u003e It should be stored at −20°C in a light-protected, moisture-free environment to maintain its structural integrity and experimental reproducibility.\u003c\/p\u003e","brand":"BioLink Analytica","offers":[{"title":"Default Title","offer_id":45052506996805,"sku":null,"price":59.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0729\/0060\/8069\/files\/TB500_ThymosinB4Acetate_-10.png?v=1785342505","url":"https:\/\/www.biolinkanalytica.com\/products\/tb500","provider":"BioLink Analytica","version":"1.0","type":"link"}