{"product_id":"other-example-product-4","title":"GHK-CU","description":"\u003ch1 data-path-to-node=\"2\"\u003eGHK-Cu (Copper Tripeptide-1) Analytical Reagent\u003c\/h1\u003e\n\u003cp data-path-to-node=\"3\"\u003e\u003cb data-path-to-node=\"3\" data-index-in-node=\"0\"\u003eGHK-Cu\u003c\/b\u003e is a high-purity, naturally occurring copper-complexed tripeptide, provided as a stable lyophilized powder strictly for \u003ci data-path-to-node=\"3\" data-index-in-node=\"127\"\u003ein vitro\u003c\/i\u003e laboratory investigation. Structurally defined as Glycyl-L-Histidyl-L-Lysine complexed with Cu²⁺, this compound is extensively documented in peer-reviewed literature for its pivotal roles in extracellular matrix (ECM) regulation, copper coordination chemistry, and diverse cellular signaling pathways.\u003c\/p\u003e\n\u003cul data-path-to-node=\"4\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"4,0,0\"\u003e\u003cb data-path-to-node=\"4,0,0\" data-index-in-node=\"0\"\u003eQuantity:\u003c\/b\u003e Supplied at 50 analytical mass units.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"4,1,0\"\u003e\u003cb data-path-to-node=\"4,1,0\" data-index-in-node=\"0\"\u003eQuality Control:\u003c\/b\u003e Uncompromising quality guaranteed, with ≥99% purity verified by RP-HPLC and molecular identity confirmed via LC-MS.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"4,2,0\"\u003e\u003cb data-path-to-node=\"4,2,0\" data-index-in-node=\"0\"\u003eRegulatory Warning:\u003c\/b\u003e This product is an analytical research reagent. It is strictly prohibited for human or animal consumption, parenteral administration, or any application outside a controlled laboratory setting.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"6\"\u003eTechnical Specifications\u003c\/h2\u003e\n\u003cul data-path-to-node=\"7\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,0,0\"\u003e\u003cb data-path-to-node=\"7,0,0\" data-index-in-node=\"0\"\u003eChemical Class:\u003c\/b\u003e Copper-Complexed Tripeptide Reagent\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,1,0\"\u003e\u003cb data-path-to-node=\"7,1,0\" data-index-in-node=\"0\"\u003eINCI Name:\u003c\/b\u003e Copper Tripeptide-1\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,2,0\"\u003e\u003cb data-path-to-node=\"7,2,0\" data-index-in-node=\"0\"\u003ePhysical Format:\u003c\/b\u003e Lyophilized Powder, Hermetically Sealed Sterile Container\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,3,0\"\u003e\u003cb data-path-to-node=\"7,3,0\" data-index-in-node=\"0\"\u003eNet Reagent Content:\u003c\/b\u003e 50 analytical mass units per sealed container\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,4,0\"\u003e\u003cb data-path-to-node=\"7,4,0\" data-index-in-node=\"0\"\u003eCAS Registry:\u003c\/b\u003e 89030-95-5\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,5,0\"\u003e\u003cb data-path-to-node=\"7,5,0\" data-index-in-node=\"0\"\u003ePubChem CID:\u003c\/b\u003e 378611\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,6,0\"\u003e\u003cb data-path-to-node=\"7,6,0\" data-index-in-node=\"0\"\u003eMolecular Formula:\u003c\/b\u003e C₁₄H₂₃CuN₆O₄\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,7,0\"\u003e\u003cb data-path-to-node=\"7,7,0\" data-index-in-node=\"0\"\u003eMolecular Weight:\u003c\/b\u003e 340.4 Da (peptide backbone) + Cu²⁺ coordination\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,8,0\"\u003e\u003cb data-path-to-node=\"7,8,0\" data-index-in-node=\"0\"\u003eAnalytical Purity:\u003c\/b\u003e ≥99% by RP-HPLC\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,9,0\"\u003e\u003cb data-path-to-node=\"7,9,0\" data-index-in-node=\"0\"\u003eIdentity Confirmation:\u003c\/b\u003e LC-MS (Molecular weight and sequence verified)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,10,0\"\u003e\u003cb data-path-to-node=\"7,10,0\" data-index-in-node=\"0\"\u003eEndotoxin Screening:\u003c\/b\u003e \u0026lt;0.25 EU (LAL assay)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,11,0\"\u003e\u003cb data-path-to-node=\"7,11,0\" data-index-in-node=\"0\"\u003eCopper Stoichiometry:\u003c\/b\u003e Cu:peptide ratio verified by ICP or colorimetric method\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,12,0\"\u003e\u003cb data-path-to-node=\"7,12,0\" data-index-in-node=\"0\"\u003eReconstitution Buffer:\u003c\/b\u003e Aqueous laboratory buffer (pH 4–6 recommended for complex stability)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,13,0\"\u003e\u003cb data-path-to-node=\"7,13,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e 2–8°C, desiccated, light-protected\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,14,0\"\u003e\u003cb data-path-to-node=\"7,14,0\" data-index-in-node=\"0\"\u003eStorage (In Solution):\u003c\/b\u003e −20°C, single-use aliquots advised\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,15,0\"\u003e\u003cb data-path-to-node=\"7,15,0\" data-index-in-node=\"0\"\u003eRegulatory Class:\u003c\/b\u003e Research Use Only (RUO)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"9\"\u003eCopper Coordination Chemistry \u0026amp; Research Mechanisms\u003c\/h2\u003e\n\u003cp data-path-to-node=\"10\"\u003eUnlike single-mechanism research tools, GHK-Cu operates across multiple documented signaling pathways simultaneously, making it uniquely valuable for investigating the intersection of copper coordination chemistry, ECM remodeling, and inflammatory pathway modulation.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"11\"\u003eCoordination Chemistry Profile\u003c\/h3\u003e\n\u003cul data-path-to-node=\"12\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"12,0,0\"\u003e\u003cb data-path-to-node=\"12,0,0\" data-index-in-node=\"0\"\u003eCu²⁺ Coordination Sites:\u003c\/b\u003e Imidazole N (His) + alpha-amino N (Gly) + deprotonated amide N\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"12,1,0\"\u003e\u003cb data-path-to-node=\"12,1,0\" data-index-in-node=\"0\"\u003eLog Stability Constant:\u003c\/b\u003e ~16.44 (PMC3359723)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"12,2,0\"\u003e\u003cb data-path-to-node=\"12,2,0\" data-index-in-node=\"0\"\u003eConditional Kd at pH 7.4:\u003c\/b\u003e Picomolar range (PMC7503498)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"12,3,0\"\u003e\u003cb data-path-to-node=\"12,3,0\" data-index-in-node=\"0\"\u003eComplex Stability:\u003c\/b\u003e Most stable between pH 4–6; dissociation occurs at extreme pH levels.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"12,4,0\"\u003e\u003cb data-path-to-node=\"12,4,0\" data-index-in-node=\"0\"\u003eRedox Chemistry:\u003c\/b\u003e Cu(II)GHK is reduced by glutathione via thiolate intermediates (PMC8653159).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"13\"\u003e2026 Laboratory Applications\u003c\/h3\u003e\n\u003col start=\"1\" data-path-to-node=\"14\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,0,0\"\u003e\u003cb data-path-to-node=\"14,0,0\" data-index-in-node=\"0\"\u003eECM Remodeling \u0026amp; Collagen Synthesis:\u003c\/b\u003e Investigated for the stimulation of collagen synthesis in fibroblast cultures at pico-to-nanomolar concentrations, and differential regulation of small proteoglycans (decorin upregulated; biglycan downregulated).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,1,0\"\u003e\u003cb data-path-to-node=\"14,1,0\" data-index-in-node=\"0\"\u003eMMP\/TIMP Protease Balance:\u003c\/b\u003e Used to study the modulation of metalloproteinases and inhibitors, consistent with a tissue-remodeling phenotype.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,2,0\"\u003e\u003cb data-path-to-node=\"14,2,0\" data-index-in-node=\"0\"\u003eAnti-Inflammatory Pathway Modulation:\u003c\/b\u003e Applied in research extending to SIRT1 activation, p-STAT3 downregulation, improvement of mucosal barrier proteins (ZO-1, occludin), and reduction of Th17-driven inflammatory signaling.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,3,0\"\u003e\u003cb data-path-to-node=\"14,3,0\" data-index-in-node=\"0\"\u003eBiomaterials \u0026amp; Delivery Systems:\u003c\/b\u003e Utilized in the development of advanced delivery systems, including dimeric copper-peptide hydrogels and pH-responsive biomaterials.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch2 data-path-to-node=\"16\"\u003eComparative Research Context\u003c\/h2\u003e\n\u003ctable data-path-to-node=\"17\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFeature\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eGHK-Cu\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eMatrixyl (Pal-KTTKS)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eLL-37\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eGHK (Apo-peptide)\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,1,0,0\"\u003e\u003cb data-path-to-node=\"17,1,0,0\" data-index-in-node=\"0\"\u003eChemical Class\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,1,1,0\"\u003eCu²⁺-complexed tripeptide\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,1,2,0\"\u003eα-amino fatty acid pentapeptide\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,1,3,0\"\u003eHost-defense cathelicidin\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,1,4,0\"\u003eApo-tripeptide (no copper)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,2,0,0\"\u003e\u003cb data-path-to-node=\"17,2,0,0\" data-index-in-node=\"0\"\u003ePrimary Research Focus\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,2,1,0\"\u003eECM + copper coordination + NF-κB\/SIRT1\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,2,2,0\"\u003eCollagen synthesis only\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,2,3,0\"\u003eAntimicrobial + immune\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,2,4,0\"\u003eECM (without copper activity)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,3,0,0\"\u003e\u003cb data-path-to-node=\"17,3,0,0\" data-index-in-node=\"0\"\u003eCopper Activity\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,3,1,0\"\u003eCu²⁺ coordination verified\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,3,2,0\"\u003eNone\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,3,3,0\"\u003eNone\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,3,4,0\"\u003eAbsent\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,4,0,0\"\u003e\u003cb data-path-to-node=\"17,4,0,0\" data-index-in-node=\"0\"\u003eCytokine Regulation\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,4,1,0\"\u003eNF-κB, MAPK, SIRT1\/STAT3\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,4,2,0\"\u003eLimited\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,4,3,0\"\u003eLimited\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,4,4,0\"\u003eLimited\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,5,0,0\"\u003e\u003cb data-path-to-node=\"17,5,0,0\" data-index-in-node=\"0\"\u003eUS Search Volume\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,5,1,0\"\u003e90,500\/month (+1,016% YoY)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,5,2,0\"\u003eLower\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,5,3,0\"\u003eLower\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,5,4,0\"\u003eLower\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,6,0,0\"\u003e\u003cb data-path-to-node=\"17,6,0,0\" data-index-in-node=\"0\"\u003eCOA Requirement\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,6,1,0\"\u003eCu stoichiometry + HPLC + MS\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,6,2,0\"\u003eHPLC only\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,6,3,0\"\u003eHPLC + MS\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,6,4,0\"\u003eHPLC + MS\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,7,0,0\"\u003e\u003cb data-path-to-node=\"17,7,0,0\" data-index-in-node=\"0\"\u003eRegulatory Class\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,7,1,0\"\u003eRUO\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,7,2,0\"\u003eRUO\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,7,3,0\"\u003eRUO\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"17,7,4,0\"\u003eRUO\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2 data-path-to-node=\"19\"\u003eWhy Source From BioLink Analytica?\u003c\/h2\u003e\n\u003cp data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003e1. Copper Stoichiometry Verification – Beyond Basic Purity\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"20\"\u003eStandard HPLC purity confirms peptide content but cannot confirm whether copper coordination is complete, partial, or absent. Our GHK-Cu batches include verification of the Cu:peptide stoichiometric ratio, ensuring researchers receive the complexed form (Cu(II)GHK) required for copper-mediated pathway research, rather than just the apo-peptide (GHK).\u003c\/p\u003e\n\u003cp data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003e2. pH-Stable Formulation Intelligence\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"21\"\u003ePublished physicochemical characterization documents GHK-Cu complex stability as highly pH-dependent, with optimal stability at pH 4–6. Our technical data sheet includes precise storage and reconstitution buffer guidance aligned with published stability data, protecting your assay integrity from formulation-induced artifacts.\u003c\/p\u003e\n\u003cp data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003e3. Cold-Chain Integrity \u0026amp; Domestic Dispatch\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"22\"\u003eCopper-peptide complexes are highly sensitive to thermal and oxidative degradation. BioLink Analytica ships exclusively within the USA via monitored cold-chain logistics from a climate-controlled facility, completely eliminating the uncontrolled temperature excursions often documented in international shipments.\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"24\"\u003eRegulatory \u0026amp; Compliance Statement\u003c\/h2\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY (RUO). NOT FOR HUMAN OR ANIMAL APPLICATION.\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eRegulatory Status:\u003c\/b\u003e Research Use Only (RUO) under the U.S. Federal Framework.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eFDA Status:\u003c\/b\u003e No FDA-approved GHK-Cu drug product exists. It holds cosmetic ingredient status only for finished products (INCI: Copper Tripeptide-1).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,2,0\"\u003e\u003cb data-path-to-node=\"26,2,0\" data-index-in-node=\"0\"\u003eNot a Drug\/Supplement:\u003c\/b\u003e Not evaluated by the FDA for safety or efficacy in any clinical application. Not a dietary supplement, nutraceutical, or consumer product.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,3,0\"\u003e\u003cb data-path-to-node=\"26,3,0\" data-index-in-node=\"0\"\u003ePPE Required:\u003c\/b\u003e Gloves, lab coat, and protective eyewear are mandatory. Copper is biologically active; handle strictly as a bioactive chemical reagent.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,4,0\"\u003e\u003cb data-path-to-node=\"26,4,0\" data-index-in-node=\"0\"\u003eStrict Prohibition:\u003c\/b\u003e Promoting, distributing, or using this research reagent for any application involving administration to living organisms is strictly prohibited under U.S. federal law.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003ci data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eDisclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/i\u003e\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"29\"\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eQ1: Is GHK-Cu intended for consumption or administration?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"58\"\u003eA:\u003c\/b\u003e No. GHK-Cu is strictly classified as a Research Use Only (RUO) laboratory reagent. It is not approved, labeled, or intended for consumption, parenteral administration, therapeutic use, or any diagnostic application. Purchase confirms your agreement to institutional laboratory research use only.\u003c\/p\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eQ2: What is the difference between GHK (apo-peptide) and GHK-Cu?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"65\"\u003eA:\u003c\/b\u003e GHK is the apo-tripeptide (glycyl-L-histidyl-L-lysine) \u003ci data-path-to-node=\"31\" data-index-in-node=\"123\"\u003ewithout\u003c\/i\u003e copper coordination. GHK-Cu is the copper-complexed form where Cu²⁺ is coordinated by the imidazole nitrogen of histidine, the alpha-amino group of glycine, and the deprotonated amide nitrogen. Researchers requiring copper-mediated pathway investigation must use the complexed GHK-Cu form to ensure proper redox reactivity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eQ3: What analytical data is provided with each batch?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"54\"\u003eA:\u003c\/b\u003e Each batch includes: (1) RP-HPLC purity ≥99%, (2) LC-MS molecular weight confirmation, (3) Cu:peptide stoichiometric ratio verification, (4) endotoxin screening \u0026lt;0.25 EU, (5) lot number for full traceability, and (6) storage and stability conditions. A comprehensive Certificate of Analysis (COA) is available per batch.\u003c\/p\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eQ4: What is the recommended reconstitution buffer for laboratory use?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"70\"\u003eA:\u003c\/b\u003e GHK-Cu complex stability is optimally maintained at pH 4–6. For most \u003ci data-path-to-node=\"33\" data-index-in-node=\"142\"\u003ein-vitro\u003c\/i\u003e assays, an aqueous buffer at pH 5–6 is recommended. Researchers must verify pH compatibility with their specific cell culture medium and assay conditions, and design experiments with appropriate redox controls.\u003c\/p\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eQ5: What is the FDA regulatory status of GHK-Cu?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"49\"\u003eA:\u003c\/b\u003e In the US, it has three distinct contexts: (1) As a cosmetic ingredient (INCI: copper tripeptide-1) in finished products. (2) As a research chemical, compliant with laboratory safety frameworks (OSHA). (3) As a compounded substance under Section 503A\/503B oversight. \u003cb data-path-to-node=\"34\" data-index-in-node=\"319\"\u003eNo FDA-approved GHK-Cu drug product exists.\u003c\/b\u003e This product is supplied exclusively as an RUO reagent.\u003c\/p\u003e\n\u003cp data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eQ6: Is GHK-Cu the same as Matrixyl or other cosmetic research peptides?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"72\"\u003eA:\u003c\/b\u003e No. Matrixyl (Pal-KTTKS) is a fatty acid-conjugated pentapeptide with a different amino acid sequence and no copper coordination activity. GHK-Cu is uniquely characterized by its Cu²⁺ chelation chemistry, making them chemically and mechanistically distinct compounds.\u003c\/p\u003e","brand":"BioLink Analytica","offers":[{"title":"50mg","offer_id":44904708636741,"sku":"GHK-CU-50","price":99.0,"currency_code":"USD","in_stock":true},{"title":"100mg","offer_id":44904708735045,"sku":"GHK-CU-100","price":190.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0729\/0060\/8069\/files\/GHKCU_-_CU50.png?v=1782365652","url":"https:\/\/www.biolinkanalytica.com\/products\/other-example-product-4","provider":"BioLink Analytica","version":"1.0","type":"link"}