{"product_id":"melanotan-2","title":"MELANOTAN-2","description":"\u003ch1 data-path-to-node=\"0\"\u003eMelanotan 2 (Cyclic Heptapeptide Lactam)\u003c\/h1\u003e\n\u003cblockquote data-path-to-node=\"1\"\u003e\n\u003cp data-path-to-node=\"1,0\"\u003e\u003cb data-path-to-node=\"1,0\" data-index-in-node=\"0\"\u003eDISCLAIMER:\u003c\/b\u003e For Research Use Only (RUO). Not for human or veterinary use. Not for cosmetic application.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp data-path-to-node=\"2\"\u003eMelanotan II (MT-II) is a synthetic cyclic heptapeptide engineered to act as a potent, non-selective agonist of the melanocortin peptide receptor family (MC1R, MC3R, MC4R, MC5R). Unlike the linear endogenous hormone α-MSH, Melanotan II utilizes a lactam bridge cyclization to enhance enzymatic stability and receptor binding affinity. It is supplied strictly for laboratory investigation into melanogenesis signaling, central nervous system (CNS) arousal pathways, and metabolic regulation. As a compound classified in FDA 503A Category 2 (Significant Safety Risks), it is intended solely for controlled \u003ci data-path-to-node=\"2\" data-index-in-node=\"604\"\u003ein vitro\u003c\/i\u003e and \u003ci data-path-to-node=\"2\" data-index-in-node=\"617\"\u003ein vivo\u003c\/i\u003e animal model research.\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"4\"\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable data-path-to-node=\"5\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eProperty\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eSpecification\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,1,0,0\"\u003e\u003cb data-path-to-node=\"5,1,0,0\" data-index-in-node=\"0\"\u003eChemical Name\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,1,1,0\"\u003eAc-Nle-cyclo-NH2\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,2,0,0\"\u003e\u003cb data-path-to-node=\"5,2,0,0\" data-index-in-node=\"0\"\u003eSystematic Name\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,2,1,0\"\u003eN-acetyl-L-norleucyl-L-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide (2→7)-lactam\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,3,0,0\"\u003e\u003cb data-path-to-node=\"5,3,0,0\" data-index-in-node=\"0\"\u003ePeptide Classification\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,3,1,0\"\u003eSynthetic cyclic lactam analogue of alpha-melanocyte-stimulating hormone (α-MSH)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,4,0,0\"\u003e\u003cb data-path-to-node=\"5,4,0,0\" data-index-in-node=\"0\"\u003ePeptide Type\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,4,1,0\"\u003eNon-selective melanocortin receptor agonist\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,5,0,0\"\u003e\u003cb data-path-to-node=\"5,5,0,0\" data-index-in-node=\"0\"\u003eMolecular Formula\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,5,1,0\"\u003eC₅₀H₆₉N₁₅O₉\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,6,0,0\"\u003e\u003cb data-path-to-node=\"5,6,0,0\" data-index-in-node=\"0\"\u003eMolecular Weight\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,6,1,0\"\u003e1024.2 g\/mol\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,7,0,0\"\u003e\u003cb data-path-to-node=\"5,7,0,0\" data-index-in-node=\"0\"\u003eCAS Registry Number\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,7,1,0\"\u003e121062-08-6\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,8,0,0\"\u003e\u003cb data-path-to-node=\"5,8,0,0\" data-index-in-node=\"0\"\u003ePurity\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,8,1,0\"\u003e≥98% (HPLC verified; specifically tested for D-Phe7 racemization impurities)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,9,0,0\"\u003e\u003cb data-path-to-node=\"5,9,0,0\" data-index-in-node=\"0\"\u003eSolubility\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,9,1,0\"\u003eSoluble in sterile water and dilute acetic acid; stability is pH-dependent\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,10,0,0\"\u003e\u003cb data-path-to-node=\"5,10,0,0\" data-index-in-node=\"0\"\u003eStorage\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,10,1,0\"\u003eLyophilized powder at \u003cb data-path-to-node=\"5,10,1,0\" data-index-in-node=\"22\"\u003e-20°C\u003c\/b\u003e, protected from light and moisture\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,11,0,0\"\u003e\u003cb data-path-to-node=\"5,11,0,0\" data-index-in-node=\"0\"\u003eMolecular Structure\u003c\/b\u003e\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan data-path-to-node=\"5,11,1,0\"\u003eFeatures a critical lactam bridge between Asp5 and Lys10 residues to stabilize the reverse-turn conformation\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2 data-path-to-node=\"7\"\u003eDescription\u003c\/h2\u003e\n\u003cp data-path-to-node=\"8\"\u003eMelanotan 2 is a superpotent melanocortin analog developed to overcome the rapid enzymatic degradation of natural α-MSH. Through rational drug design, the inclusion of D-Phenylalanine (D-Phe) at position 7 and the formation of a covalent lactam bridge between Aspartic Acid (residue 5) and Lysine (residue 10) constrain the peptide into a rigid beta-turn conformation.\u003c\/p\u003e\n\u003cp data-path-to-node=\"9\"\u003eThis structural modification significantly increases its binding affinity (Ki) across multiple melanocortin receptor subtypes, specifically \u003cb data-path-to-node=\"9\" data-index-in-node=\"140\"\u003eMC1R\u003c\/b\u003e (pigmentation) and \u003cb data-path-to-node=\"9\" data-index-in-node=\"164\"\u003eMC4R\u003c\/b\u003e (energy homeostasis and neuro-signaling).\u003c\/p\u003e\n\u003cp data-path-to-node=\"10\"\u003eIn the research context, Melanotan 2 serves as a critical probe for mapping the central melanocortin system. It is extensively utilized to study the pathophysiology of energy balance, the regulation of tyrosinase activity in melanocytes, and the hemodynamic effects of sympathomimetic activation. Due to its ability to cross the blood-brain barrier in animal models, it remains a primary tool for investigating neuro-mediated physiological responses.\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"12\"\u003eExperimental \u0026amp; Analytical Use\u003c\/h2\u003e\n\u003cp data-path-to-node=\"13\"\u003eMelanotan 2 is utilized in laboratory research for several primary applications:\u003c\/p\u003e\n\u003cul data-path-to-node=\"14\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,0,0\"\u003e\u003cb data-path-to-node=\"14,0,0\" data-index-in-node=\"0\"\u003eReceptor Kinetics:\u003c\/b\u003e Determining binding constants (Ki) and signal transduction efficacy at MC1R vs. MC4R interfaces.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,1,0\"\u003e\u003cb data-path-to-node=\"14,1,0\" data-index-in-node=\"0\"\u003eMetabolic Signaling:\u003c\/b\u003e Investigating lipolysis and appetite suppression pathways in rodent obesity models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,2,0\"\u003e\u003cb data-path-to-node=\"14,2,0\" data-index-in-node=\"0\"\u003eToxicology Modeling:\u003c\/b\u003e Studying the mechanisms of sympathomimetic toxicity, renal vasoconstriction, and rhabdomyolysis in high-dose scenarios.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,3,0\"\u003e\u003cb data-path-to-node=\"14,3,0\" data-index-in-node=\"0\"\u003eNeurophysiology:\u003c\/b\u003e Exploring the role of MC4R activation in CNS arousal and thermoregulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"14,4,0\"\u003e\u003cb data-path-to-node=\"14,4,0\" data-index-in-node=\"0\"\u003eAnalytical Calibration:\u003c\/b\u003e Serving as a reference standard for LC-MS\/MS detection of peptide impurities and metabolites in forensic toxicology.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"15\"\u003eToxicology and Detection Methods\u003c\/h3\u003e\n\u003cp data-path-to-node=\"16\"\u003eFor forensic and anti-doping research, Melanotan 2 is identified in biological matrices using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS\/MS).\u003c\/p\u003e\n\u003cul data-path-to-node=\"17\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"17,0,0\"\u003e\u003cb data-path-to-node=\"17,0,0\" data-index-in-node=\"0\"\u003ePrimary Analyte:\u003c\/b\u003e The intact parent peptide is monitored using the doubly charged precursor ion \u003cspan class=\"math-inline\" data-math=\"[M+2H]^{2+}\" data-index-in-node=\"95\"\u003e$[M+2H]^{2+}$\u003c\/span\u003e at m\/z 513.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"17,1,0\"\u003e\u003cb data-path-to-node=\"17,1,0\" data-index-in-node=\"0\"\u003eMetabolite Profile:\u003c\/b\u003e Research indicates Melanotan 2 resists rapid hydrolysis due to the lactam bridge, but metabolites resulting from deamidation and C-terminal cleavage can be detected.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"17,2,0\"\u003e\u003cb data-path-to-node=\"17,2,0\" data-index-in-node=\"0\"\u003eAdverse Event Mechanisms:\u003c\/b\u003e Investigational models use MT-II to study renal infarction pathways, specifically hypothesizing that non-selective MCR activation triggers severe sympathetic vasoconstriction and thrombotic microangiopathy in renal vasculature.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"18\"\u003e\u003ci data-path-to-node=\"18\" data-index-in-node=\"0\"\u003e(Note: These analytical methods are used exclusively for forensic, anti-doping, and laboratory toxicology research.)\u003c\/i\u003e\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"20\"\u003eHandling and Stability\u003c\/h2\u003e\n\u003cp data-path-to-node=\"21\"\u003eMelanotan 2 is supplied as a lyophilized white powder (acetate salt).\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e Soluble in sterile bacteriostatic water. However, for extended stability during assays, reconstitution in dilute acetic acid (0.1%) is often preferred to prevent base-catalyzed deamidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eLactam Bridge Sensitivity:\u003c\/b\u003e While the cyclic structure confers serum stability, the peptide is sensitive to hydrolysis at extreme pH. \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"133\"\u003eAvoid repeated freeze-thaw cycles\u003c\/b\u003e which can disrupt conformational integrity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eStorage Instructions:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"22,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,1,0,0\"\u003eStore lyophilized vials in a sealed container at \u003cb data-path-to-node=\"22,2,1,0,0\" data-index-in-node=\"49\"\u003e-20°C\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,1,1,0\"\u003eProtect from UV light and moisture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,1,2,0\"\u003eReconstituted aliquots should be used immediately or stored at \u003cb data-path-to-node=\"22,2,1,2,0\" data-index-in-node=\"63\"\u003e-80°C\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,1,3,0\"\u003eMaintain strictly within an RUO-standard laboratory environment.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"24\"\u003eMolecular \u0026amp; Technical Characteristics\u003c\/h2\u003e\n\u003cp data-path-to-node=\"25\"\u003eSynthesized using Solid Phase Peptide Synthesis (SPPS), Profound Aminos' Melanotan 2 is purified to eliminate synthesis-related impurities:\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eStereochemical Purity:\u003c\/b\u003e Rigorous testing ensures the D-Phe7 residue has not racemized during synthesis, which would otherwise alter receptor selectivity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eImpurity Profile:\u003c\/b\u003e Complete elimination of \"failure sequences\" and aspartimide byproducts frequently found in lower-grade preparations.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,2,0\"\u003e\u003cb data-path-to-node=\"26,2,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e The N-acetyl and C-amidated termini provide resistance to exopeptidases, making it highly suitable for prolonged \u003ci data-path-to-node=\"26,2,0\" data-index-in-node=\"124\"\u003ein vivo\u003c\/i\u003e animal studies compared to linear peptides.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"27\"\u003eScientific Significance\u003c\/h3\u003e\n\u003cp data-path-to-node=\"28\"\u003eThe study of Melanotan 2 contributes to the broader understanding of:\u003c\/p\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003eGPCR Pharmacology:\u003c\/b\u003e Ligand-receptor interaction dynamics of Class A G-Protein Coupled Receptors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eSympathetic Nervous System:\u003c\/b\u003e The role of melanocortins in blood pressure regulation and renal hemodynamics.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,2,0\"\u003e\u003cb data-path-to-node=\"29,2,0\" data-index-in-node=\"0\"\u003eImmunogenicity:\u003c\/b\u003e The FDA has flagged Melanotan 2 for potential immunogenicity risks (development of anti-drug antibodies) due to peptide aggregation, making it a subject of interest for immunological safety research.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"31\"\u003eRUO Compliance \u0026amp; Regulatory Status\u003c\/h2\u003e\n\u003cblockquote data-path-to-node=\"32\"\u003e\n\u003cp data-path-to-node=\"32,0\"\u003e\u003cb data-path-to-node=\"32,0\" data-index-in-node=\"0\"\u003eAll experimental applications of Melanotan 2 must be conducted under Research Use Only (RUO) protocols.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003eFDA Status:\u003c\/b\u003e Placed on the 503A Bulks List Category 2 (Significant Safety Risks) as of late 2023\/2024. It is strictly prohibited for use in compounding for human administration.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eWADA Status:\u003c\/b\u003e Explicitly prohibited under Section S2 (Peptide Hormones).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eIntended Use:\u003c\/b\u003e Not for diagnostic, therapeutic, cosmetic, or veterinary purposes.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"35\"\u003eFeatures \/ Highlights\u003c\/h2\u003e\n\u003cul data-path-to-node=\"36\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,0,0\"\u003ePotent, non-selective agonist of MC1R, MC3R, MC4R, and MC5R.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,1,0\"\u003eCyclic heptapeptide structure with verified lactam bridge integrity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,0\"\u003eEnables investigation into sympathomimetic toxicity and renal pathophysiology.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,3,0\"\u003eVerified \u003cb data-path-to-node=\"36,3,0\" data-index-in-node=\"9\"\u003e≥98% purity\u003c\/b\u003e via HPLC to minimize D-Phe7 racemization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,4,0\"\u003eHigh stability profile compared to linear α-MSH.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,5,0\"\u003eStrictly designed and labeled for \u003cb data-path-to-node=\"36,5,0\" data-index-in-node=\"34\"\u003eResearch Use Only (RUO)\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"38\"\u003eWhy Profound Aminos?\u003c\/h2\u003e\n\u003cp data-path-to-node=\"39\"\u003eProfound Aminos supplies high-purity Melanotan 2 (Acetate) for controlled pharmacological, toxicological, and receptor-binding research programs. Researchers value our commitment to quality through:\u003c\/p\u003e\n\u003col start=\"1\" data-path-to-node=\"40\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,0,0\"\u003e\u003cb data-path-to-node=\"40,0,0\" data-index-in-node=\"0\"\u003eStereochemical Validation:\u003c\/b\u003e RUO-grade Melanotan 2 with verified D-Phenylalanine integrity ensures accurate receptor binding data (Ki).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,1,0\"\u003e\u003cb data-path-to-node=\"40,1,0\" data-index-in-node=\"0\"\u003eImpurity Transparency:\u003c\/b\u003e Rigorous removal of synthesis byproducts that can skew immunogenicity and toxicity assays.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,2,0\"\u003e\u003cb data-path-to-node=\"40,2,0\" data-index-in-node=\"0\"\u003eMass Spec Verification:\u003c\/b\u003e Identity confirmation matching the specific cyclic mass (1024.2 Da) detects potential ring-opening degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,3,0\"\u003e\u003cb data-path-to-node=\"40,3,0\" data-index-in-node=\"0\"\u003eRegulatory Awareness:\u003c\/b\u003e Clear documentation and labeling align with FDA 503A Category 2 safety advisories.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp data-path-to-node=\"41\"\u003e\u003ci data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eProfound Aminos is the trusted choice for research organizations studying melanocortin signaling, renal hemodynamics, and peptide toxicology.\u003c\/i\u003e\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"43\"\u003eFrequently Asked Questions (FAQs)\u003c\/h2\u003e\n\u003cp data-path-to-node=\"44\"\u003e\u003cb data-path-to-node=\"44\" data-index-in-node=\"0\"\u003eQ1: What is the primary research application of Melanotan 2?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"44\"\u003eMelanotan 2 is used to investigate the signaling pathways of melanocortin receptors (MC1R-MC5R), specifically studying effects on energy homeostasis, CNS arousal, and melanogenesis in animal models.\u003c\/p\u003e\n\u003cp data-path-to-node=\"45\"\u003e\u003cb data-path-to-node=\"45\" data-index-in-node=\"0\"\u003eQ2: How does Melanotan 2 differ from Melanotan I?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"45\"\u003eMelanotan 2 is a cyclic heptapeptide with a lactam bridge and non-selective binding affinity (including MC4R), whereas Melanotan I is a linear peptide with higher selectivity primarily for MC1R.\u003c\/p\u003e\n\u003cp data-path-to-node=\"46\"\u003e\u003cb data-path-to-node=\"46\" data-index-in-node=\"0\"\u003eQ3: Why is Melanotan 2 listed as an FDA Category 2 substance?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"46\"\u003eThe FDA placed Melanotan 2 in Category 2 due to significant safety risks identified in research, including immunogenicity (immune reaction to the peptide) and the potential for renal and cardiovascular toxicity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"47\"\u003e\u003cb data-path-to-node=\"47\" data-index-in-node=\"0\"\u003eQ4: How should Melanotan 2 be stored for optimal stability?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"47\"\u003eIt should be stored as a lyophilized powder at -20°C. Once reconstituted, the lactam bridge can degrade over time; therefore, immediate use or storage at -80°C is highly recommended.\u003c\/p\u003e\n\u003cp data-path-to-node=\"48\"\u003e\u003cb data-path-to-node=\"48\" data-index-in-node=\"0\"\u003eQ5: Is Melanotan 2 suitable for human use?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"48\"\u003e\u003cb data-path-to-node=\"48\" data-index-in-node=\"43\"\u003eNo.\u003c\/b\u003e Melanotan 2 is strictly for Research Use Only (RUO) and is not approved for human consumption, cosmetic tanning, or therapeutic use.\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"50\"\u003eReferences\u003c\/h2\u003e\n\u003col start=\"1\" data-path-to-node=\"51\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,0,0\"\u003eNelson ME, Bryant SM, Aks SE. Melanotan 2 injection resulting in systemic toxicity and rhabdomyolysis. \u003ci data-path-to-node=\"51,0,0\" data-index-in-node=\"103\"\u003eClin Toxicol (Phila)\u003c\/i\u003e. 2012;50(10):1169-1173.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,1,0\"\u003eU.S. Food and Drug Administration (FDA). Pharmacy Compounding Advisory Committee (PCAC) Briefing Document: Melanotan 2. \u003ci data-path-to-node=\"51,1,0\" data-index-in-node=\"120\"\u003eFDA.gov\u003c\/i\u003e. Published October 2024. Accessed December 2025.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,2,0\"\u003ePeters B, Hadimeri H, Wahlberg R, Afghahi H. Melanotan 2: a possible cause of renal infarction: review of the literature and case report. \u003ci data-path-to-node=\"51,2,0\" data-index-in-node=\"138\"\u003eCEN Case Rep\u003c\/i\u003e. 2020;9(2):159-161. doi:10.1007\/s13730-020-00447-z.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,3,0\"\u003eWorld Anti-Doping Agency (WADA). The 2025 Prohibited List: International Standard. Section S2: Peptide Hormones, Growth Factors, Related Substances, and Mimetics. \u003ci data-path-to-node=\"51,3,0\" data-index-in-node=\"163\"\u003eWADA-ama.org\u003c\/i\u003e. Effective January 1, 2025.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,4,0\"\u003eBreindahl T, Evans-Brown M, Hindersson P, et al. Identification and characterization by LC-UV-MS\/MS of melanotan 2 skin-tanning products sold illegally on the Internet. \u003ci data-path-to-node=\"51,4,0\" data-index-in-node=\"169\"\u003eDrug Test Anal\u003c\/i\u003e. 2015;7(2):164-172.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,5,0\"\u003eHadley ME, Hruby VJ, Blanchard J, et al. Discovery and development of novel melanogenic drugs. Melanotan-I and -II. \u003ci data-path-to-node=\"51,5,0\" data-index-in-node=\"116\"\u003ePharm Biotechnol\u003c\/i\u003e. 1998;11:575-595.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,6,0\"\u003eDorr RT, Lines R, Levine N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. \u003ci data-path-to-node=\"51,6,0\" data-index-in-node=\"140\"\u003eLife Sci\u003c\/i\u003e. 1996;58(20):1777-1784.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,7,0\"\u003eVanhee C, Janvier S, Desmedt B, et al. Analysis of illegal peptide biopharmaceuticals: Amino acid analysis and active pharmaceutical ingredient (API) identification. \u003ci data-path-to-node=\"51,7,0\" data-index-in-node=\"166\"\u003eTalanta\u003c\/i\u003e. 2015;144:63-70.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"51,8,0\"\u003eNavarro M, Cubero I, Chen AS, et al. Effects of Melanotan-II, a melanocortin agonist, on ethanol intake and neurochemistry in P rats. \u003ci data-path-to-node=\"51,8,0\" data-index-in-node=\"134\"\u003ePharmacol Biochem Behav\u003c\/i\u003e. 2002;72:149.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cblockquote data-path-to-node=\"52\"\u003e\n\u003cp data-path-to-node=\"52,0\"\u003e\u003cb data-path-to-node=\"52,0\" data-index-in-node=\"0\"\u003eRUO DISCLAIMER:\u003c\/b\u003e This compound is for \u003cb data-path-to-node=\"52,0\" data-index-in-node=\"37\"\u003eResearch Use Only (RUO)\u003c\/b\u003e. It is not intended for human, veterinary, or cosmetic applications. All information provided is based on peer-reviewed scientific literature and intended solely for laboratory and academic research purposes. This product is not a dietary supplement or drug.\u003c\/p\u003e\n\u003c\/blockquote\u003e","brand":"BioLink Analytica","offers":[{"title":"Default Title","offer_id":45053679927365,"sku":null,"price":59.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0729\/0060\/8069\/files\/MT2_-_ML10.png?v=1782365654","url":"https:\/\/www.biolinkanalytica.com\/products\/melanotan-2","provider":"BioLink Analytica","version":"1.0","type":"link"}