{"product_id":"epithalon","title":"EPITHALON","description":"\u003ch2 data-path-to-node=\"6\"\u003eDescription\u003c\/h2\u003e\n\u003ch3 data-path-to-node=\"7\"\u003eOverview \u0026amp; Core Use Cases\u003c\/h3\u003e\n\u003cp data-path-to-node=\"8\"\u003eEpithalon (AEDG) (also known as Epitalon \/ Epithalamin or Ala-Glu-Asp-Gly) is a synthetic tetrapeptide widely utilized in molecular aging and regenerative biology research. Originally investigated for its connection to pineal gland function, it has become a premier compound for studying telomere biology and DNA protection. Its consistency, high purity, and ease of handling make it an optimal choice for laboratories exploring telomerase activation, chromatin remodeling, and overall genome maintenance.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"9\"\u003eCellular Uptake \u0026amp; Chromatin\/DNA Context\u003c\/h3\u003e\n\u003cp data-path-to-node=\"10\"\u003eDue to its small molecular size, Epithalon readily penetrates cellular membranes to reach the nucleus. This makes it an invaluable tool for examining how cells manage DNA damage, age-related genetic mutations, and chromatin remodeling. It is also highly relevant in epigenetic research; studies suggest interactions with DNA and histone-related proteins, allowing researchers to explore shifts in gene expression caused by aging or cellular stress. These properties make it highly valuable for experiments focused on methylation, chromatin structure, and transcriptional control.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"11\"\u003eTelomerase \u0026amp; Telomere Maintenance\u003c\/h3\u003e\n\u003cp data-path-to-node=\"12\"\u003eA primary research focus for this peptide is telomerase activity. Telomerase is responsible for maintaining telomeres, the protective caps at the ends of chromosomes. Multiple in-vitro models indicate that Epithalon elevates hTERT expression, promoting telomere extension. This enables researchers to effectively test how telomere length influences cellular aging, genome stability, and replication limits.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"13\"\u003eCircadian\/Melatonin \u0026amp; Oxidative Stress\u003c\/h3\u003e\n\u003cp data-path-to-node=\"14\"\u003eEpithalon is also frequently utilized to study the melatonin pathway. Evidence from laboratory studies indicates that the peptide supports pineal signaling and circadian regulation, providing a controlled model for observing oxidative defense and neuroendocrine timing. Furthermore, in cell cultures and animal studies, it has been associated with reduced oxidative damage and improved DNA repair signals, making it a staple in experiments concerning chromosome integrity and age-related molecular degradation.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"15\"\u003ePractical Use \u0026amp; Combinatorial Studies\u003c\/h3\u003e\n\u003cp data-path-to-node=\"16\"\u003eLaboratories frequently combine Epithalon with complementary compounds, such as GHK-Cu or BPC-157, to evaluate multi-peptide signaling within cell longevity models. Its stability, rigorous purity, and excellent solubility ensure straightforward integration across diverse research setups.\u003c\/p\u003e\n\u003ch2 data-path-to-node=\"18\"\u003eFeatures \u0026amp; Highlights\u003c\/h2\u003e\n\u003cul data-path-to-node=\"19\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,0,0\"\u003e\u003cb data-path-to-node=\"19,0,0\" data-index-in-node=\"0\"\u003eSupports\u003c\/b\u003e telomere and telomerase research\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,1,0\"\u003e\u003cb data-path-to-node=\"19,1,0\" data-index-in-node=\"0\"\u003eUseful\u003c\/b\u003e in chromatin and DNA stability studies\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,2,0\"\u003e\u003cb data-path-to-node=\"19,2,0\" data-index-in-node=\"0\"\u003eHighly Pure:\u003c\/b\u003e ≥99% purity (HPLC verified)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,3,0\"\u003e\u003cb data-path-to-node=\"19,3,0\" data-index-in-node=\"0\"\u003eVersatile:\u003c\/b\u003e Works well in multi-peptide comparison models\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,4,0\"\u003e\u003cb data-path-to-node=\"19,4,0\" data-index-in-node=\"0\"\u003eTargeted:\u003c\/b\u003e Suitable for oxidative stress and aging biology research\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,5,0\"\u003e\u003cb data-path-to-node=\"19,5,0\" data-index-in-node=\"0\"\u003eApplication:\u003c\/b\u003e Strictly for Research Use Only (RUO)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"21\"\u003eStorage Instructions\u003c\/h2\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003eStore at −20°C in a tightly sealed container.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003eProtect from direct light and moisture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003eAvoid repeated freeze-thaw cycles to maintain peptide integrity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"24\"\u003eSelected Research References\u003c\/h2\u003e\n\u003cul data-path-to-node=\"25\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"25,0,0\"\u003e\u003cb data-path-to-node=\"25,0,0\" data-index-in-node=\"0\"\u003eKhavinson, V. et al.\u003c\/b\u003e \"Peptide Regulation of Telomerase and Cellular Aging.\" \u003ci data-path-to-node=\"25,0,0\" data-index-in-node=\"76\"\u003eBulletin of Experimental Biology\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"25,1,0\"\u003e\u003cb data-path-to-node=\"25,1,0\" data-index-in-node=\"0\"\u003eAnisimov, V. et al.\u003c\/b\u003e \"Epithalon \/ Epitalon and Genome Stability in Cellular Models.\" \u003ci data-path-to-node=\"25,1,0\" data-index-in-node=\"84\"\u003eBiogerontology\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"25,2,0\"\u003e\u003cb data-path-to-node=\"25,2,0\" data-index-in-node=\"0\"\u003eArutyunyan, A. et al.\u003c\/b\u003e \"Pineal Peptides and Epigenetic Regulation.\" \u003ci data-path-to-node=\"25,2,0\" data-index-in-node=\"67\"\u003eAdvances in Gerontology\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"25,3,0\"\u003e\u003cb data-path-to-node=\"25,3,0\" data-index-in-node=\"0\"\u003eKhavinson, V. \u0026amp; Linkova, N.\u003c\/b\u003e \"DNA–Peptide Interaction Mechanisms in Telomere Biology.\" \u003ci data-path-to-node=\"25,3,0\" data-index-in-node=\"86\"\u003eCell Tissue Research\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cblockquote data-path-to-node=\"26\"\u003e\n\u003cp data-path-to-node=\"26,0\"\u003e\u003cb data-path-to-node=\"26,0\" data-index-in-node=\"0\"\u003eDisclaimer:\u003c\/b\u003e For Research Use Only. Not for human or veterinary use. Information is based on published scientific literature and provided solely for academic reference.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"BioLink Analytica","offers":[{"title":"10mg","offer_id":45046469066821,"sku":"EPITHALON","price":34.0,"currency_code":"USD","in_stock":true},{"title":"40mg","offer_id":45051807236165,"sku":null,"price":99.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0729\/0060\/8069\/files\/EPITHALON_10_MG.png?v=1782365655","url":"https:\/\/www.biolinkanalytica.com\/products\/epithalon","provider":"BioLink Analytica","version":"1.0","type":"link"}